When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
نویسندگان
چکیده
The CNS (central nervous system) is unquestionably the central organ that regulates directly or indirectly all physiological systems in the mammalian body. Yet, when considering the defence of the CNS from pathogens, the CNS has often been considered passive and subservient to the pro-inflammatory responses of the immune system. In this view, neuroinflammatory disorders are examples of when the tail (the immune system) wags the dog (the CNS) to the detriment of an individual's function and survival.
منابع مشابه
P 61: MicroRNA as a Therapeutic Tool to Prevent Blood Brain Barrier Dysfunction in Neuroinflammation
Endothelial cells present in brain are unique and differ from other peripheral tissues in a number of ways, which ensures specific brain endothelial barrier properties. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation. Various microRNAs (miRNA) have been discovered in different cellular components of the blood bran barrier (BBB). miRNAs a...
متن کاملP 110: Evaluating the Role of Histone Hyper Acetylation in Induction of Neuroinflammation
Microglia is the effector cell of the innate immune system in central nervous system (CNS). These cells mediate inflammatory responses in injuries. Besides external factors, microglial function is also controlled by internal factors, including epigenetic regulations. Mechanisms of epigenetic regulation mainly consist of DNA methylation, histone modifications and use of non-coding RNAs. Recent s...
متن کاملP101: Neuroinflammation and Cognitive Dysfunction as a Side Effect of Abdominal Surgery
One of the most common postoperative complications is Postoperative cognitive dysfunction (POCD), and it’s usually a geriatric’s disease. Although many studies have done, the exact molecular mechanisms of POCD is still largely unknown; nevertheless, neuroinflammation has been increasingly denoted as one of the core mechanisms for the pathogenesis of POCD. As a hypothesize, surgery-i...
متن کاملP 153: Neuroinflammation in Multiple Sclerosis
Multiple sclerosis (MS) is a complex disease which is correlated with increasing inflammatory factors, demyelination and axonal loss. In this auto-immune disease, Neuroinflammation is mediated by different types of T cells with macrophage/microglial activation and B cells involvement that interact in a collaborative manner. Focal inflammation is the main cause for the onset of relapses and coul...
متن کاملP 67: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis
Neuroinflammation as a protective mechanism for repairing tissue damage in the central nervous system (CNS), has been classified into two types: acute and chronic. It is characterized by the activation of microglia and astrocytes and the increase levels of different chemokines and cytokines. Neuroinflammation can be harmful, and it is a common pathological feature in neurodegenerative and psych...
متن کامل